本文へジャンプ

研究業績

2021

Kato H
, Shimizu M, Urano T
Chemical map-based prediction of nucleosome positioning using the Bioconductor package nuCpos
BMC Bioinfomatics 22,322, 2021

2020

Sugiura T, Kamino H, Nariai Y, Murakawa Y, Kondo M, Kawakami M, Ikeda N, Uchio Y, Urano T: Screening of a panel of low-molecular-weight compounds that inhibit synovial fibroblast invasion in rheumatoid arthritis

J. Immunol. in press

IF = 4.886 (2019)              Q2                                                                

 

Yoshida H, Park S-Y, Sakashita G, Nariai Y, Kanako K, Muto Y, Urano T,Obayashi E : Elucidation of the aberrant 3´ splice site selection by cancer-associated mutations on the U2AF1.

Nat. Commun. 11(1): 4744, 2020 doi: 10.1038/s41467-020-18559-6.

IF = 12.121 (2019)            Q1                                                                

                                                             

Chikashige Y, Kato H, Thornton M, Pepper W, Hilgers M, Cecil A, Asano I, Yamada H, Mori C, Brunkow C, Moravek C, Urano T, Singh CR, Asano K.: Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs.

Nucleic Acids Res., in press.

doi: 10.1093/nar/gkaa608. Online ahead of print.

IF = 11.501 (2019)            Q1                                                                


Kaneko N, Kurata M, Yamamoto T, Shigemura T, Agematsu K, Yamazaki T, Takeda H, Sawasaki T, Koga T, Kawakami A, Yachie A, Migita K, Yoshiura KI, Urano T, Masumoto J.: KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle-Wells syndrome.

Sci Rep., 10(1):13562, 2020

doi: 10.1038/s41598-020-70513-0.

IF = 3.998 (2019)              Q1                                                                

 

Sakai H, Murakami C, Usuki T, Lu Q, Matsumoto KI, Urano T, Sakane F.: Diacylglycerol kinase η regulates C2C12 myoblast proliferation through the mTOR signaling pathway.

Biochimie, in press.

doi: 10.1016/j.biochi.2020.07.018.

IF = 3.413 (2019)              Q2                                                  

 

Temmoku J, Fujita Y, Matsuoka N, Urano T, Furuya MY, Asano T, Sato S, Matsumoto H, Watanabe H, Kozuru H, Yatsuhashi H, Kawakami A, Migita K.: Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib.

Mod Rheumatol. 9:1-20, 2020 doi: 10.1080/14397595.2020.1740410

IF = 2.113 (2019)              Q3                                                                


2019

Fujita Y, Matsuoka N, Temmoku J, Furuya MY, Asano T, Sato S, Kobayashi H, Watanabe H, Suzuki E, Urano T, Kozuru H, Yatsuhashi H, Koga T, Kawakami A, Migita K.: Hydroxychloroquine inhibits IL-1βproduction from amyloid-stimulated human neutrophils.

Arthritis Res Ther. 21(1):250, 2019. doi: 10.1186/s13075-019-2040-6

IF = 4.103 (2019)              Q1                                                                


Sorida M, Hirauchi T, Ishizaki H, Kaito W, Shimada A, Mori C, Chikashige Y, Hiraoka Y, Suzuki Y, Ohkawa Y, Kato H, Takahata S, Murakami Y.: Regulation of ectopic heterochromatin-mediated epigeneticdiversification by the JmjC family protein Epe1.

PLoS Genet., 15(6): e1008129, 2019. doi: 10.1371/journal.pgen.1008129.

IF = 5.174 (2019)              Q1                                                   Times Cited: 3          

 

Nariai Y, Kamino H, Obayashi E, Kato H, Sakashita G, Sugiura T, Migita K, Koga T, Kawakami A, Sakamoto K, Kadomatsu K, Nakakido M, Tsumoto K, Urano T.: Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18.

Arch Biochem Biophys, 663:71-82, 2019 doi: 10.1016/j.abb.2019.01.001

IF = 3.391 (2019)              Q2                                                   Times Cited: 2          

 

Kato H, Okazaki K, Urano T.: How does Hsp90 function in RNAi-dependent heterochromatin assembly?

Curr Genet., 65: 87-91, 2019 doi: 10.1007/s00294-018-0866-0. (Review)

IF = 3.464 (2018)              Q2                                                                


浦野 健
抗体を主とした島根大学発バイオベンチャーによる事業展開. 腎臓内科・泌尿器科 9: 388-394, 2019

                                                                                                 

【特許】朴 三用、浦野 健成相 裕子、杉山 佳奈子. インフルエンザウイルスのRNA依存性RNAポリメラーゼのPB2サブユニットに対するモノクローナル抗体」 

特許6614523号(令和1年1115日)

特願2014-068824、平成26328日出願

2018

Ganasen M,Togashi H, Taeda H, Asakura H, Tosha T, Yamashita K, Hirat K, Nariai Y, Urano T, Yuan X , Hamza I, Mauk A G, Shiro Y, Sugimoto H, Sawai H: Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.
Communications biology, 1 120, 2018 doi: 10.1038/s42003-018-0121-8


Okazaki K, Kato H, Iida T, Shinmyozu K, Nakayama JI, Murakami Y, Urano T: RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.
Epigenetics Chromatin,11:26, 2018 doi: 10.1186/s13072-018-0199-8
IF = 5.189 (2016)

Sakai H, Murakami C, Matsumoto KI, Urano T, Sakane F: Diacylglycerol kinase δ controls down-regulation of cyclin D1 for C2C12 myogenic differentiation.
Biochimie, in press doi: 10.1016/j.biochi.2018.05.017
IF = 3.112 (2016)

Nakayama N, Sakashita G, Nariai Y, Kato H, Sinmyozu K, Nakayama JI, Kyo S, Urano T, Nakayama K: Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression.
Oncotarget, in press
IF = 5.168 (2016)

Sakashita G, Kiyoi H, Naoe T and Urano T: Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography
Sci Rep 8: 4008, 2018 doi: 10.1038/s41598-018-22359-w
IF = 4.259 (2016)

Ikejiri F, Honma Y, Okada T, Urano T, Suzumiya J: Cotylenin A and tyrosine kinase inhibitors synergistically inhibit the growth of chronic myeloid leukemia cells
Int J Oncol, in press
IF = 1.390 (2016)

Ikejiri F, Honma Y, Kasukabe T, Urano T, Suzumiya J: TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells.
Oncol Lett., 15: 3240-3244, 2018 doi: 10.3892/ol.2017.7713
IF = 1.390 (2016)

Ichiyama T, Nakatani E, Tatsumi K, Hideshima K, Urano T, Nariai Y, Sekine J.: Expression of aquaporin 3 and 5 as a potential marker for distinguishing dry mouth from Sjögren's syndrome.

J Oral Sci., 60: 212-220, 2018. doi: 10.2334/josnusd.17-0150.

IF=1.104(2018)              Q4                                            Times Cited: 2                                                                                                            

 

浦野 健成相 裕子加美野 宏樹尾林 栄治

活性型インターロイキンー18タンパク質のネオエピトープを認識する抗体、及びその応用

権利者国立大学法人島根大学

出願番号 特願2018-226667出願日平成30年12月3日

補正出願 特願2019-104826出願日令和元年6月4日

PCT/JP2019/47154

 

浦野 健成相 裕子尾林 栄治加美野 宏樹

検出感度の高いインターロイキンー18タンパク質に対する抗体およびその応用

権利者国立大学法人島根大学

出願番号 特願2018-072006出願日平成30年4月4日

補正出願 特願2018-246840出願日平成30年12月28日

PCT/JP2019/014748

2017
Fuse T, Katsumata K, Morohoshi K, Mukai Y, Ichikawa Y, Kurumizaka H, Yanagida A, Urano T, Kato H, Shimizu M: Parallel mapping with site-directed hydroxyl radicals and micrococcal nuclease reveals structural features of positioned nucleosomes in vivo.
PLoS One, 12: e0186974, 2017 doi: 10.1371/journal.pone.0186974.
IF = 2.806 (2016)

Seo HD, Choi Y, Kim M, Kang K, Urano T, Lee D:The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.
J Biol Chem. 292: 17144-17155, 2017 doi: 10.1074/jbc.M117.790824
IF = 4.125 (2016) 【Times Cited: 1】

Inoue M, Honma Y, Urano T, Suzumiya J.: Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Oncol Lett. 14: 792-800, 2017. doi: 10.3892/ol.2017.6219.
IF = 1.390 (2016)

Tomiyama L, Kamino H, Fukamachi H, Urano T: Precise epitope determination of the anti-vimentin monoclonal antibody V9
Mol Med Rep (2017) doi: 10.3892/mmr.2017.7102
IF = 1.692 (2016)

Tatsumi K, Sakashita G, Nariai Y, Okazaki K, Kato H, Obayashi E, Yoshida H, Sugiyama K, Park S-M, Sekine J, Urano T: G196 epitope tag system: a novel monoclonal antibody, G196, recognizes the small, soluble peptide DLVPR with high affinity.
Sci Rep 7: 43480, 2017. doi:10.1038/srep43480
IF = 4.259 (2016) 【Times Cited: 1】

Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K.: Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Cell Rep 18: 2651-2663, 2017 doi:10.1016/j.celrep.2017.02.052
IF = 8.282 (2016) 【Times Cited: 3】

浦野 健成相 裕子尾林 栄治、朴 三用、杉山 佳奈子、吉田 尚史:インフルエンザウイルスの増殖を阻害するモノクローナル抗体
権利者国立大学法人島根大学、公立大学法人 横浜市立大学、(公財)神奈川科学技術アカデミー
出願番号 特願2017-045514、出願日平成29年3月10日

2016
Nakayama N, Kato H, Sakashita G, Nariai Y, Nakayama K, Kyo S, Urano T: Protein complex formation and intranuclear dynamics of NAC1 in cancer cells
Arch Biochem Biophys 606:10-15, 2016 doi: 10.1016/j.abb.2016.07.007
IF = 3.165 (2016) 【Times Cited: 2】

Takagi M, Sakamoto T, Suzuki R, Nemoto K, Obayashi T, Matsunaga TM, Hirakawa T, Kurihara D, Nariai Y, Urano T, Sawasaki T, Matsunaga, S: Plant Aurora kinases interact with and phosphorylate transcription factors.
J Plant Res 129: 1165-1178, 2016 doi: 10.1007/s10265-016-0860-x
IF = 1.899 (2016) 【Times Cited: 1】

Suzuki S, Kato H, Suzuki Y, Chikashige Y, Hiraoka Y, Kimura H, Nagao K, Obuse C, Takahata S, and Murakami Y.: Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
Nucleic Acids Res 44: 4147-4162, 2016 doi: 10.1093/nar/gkw008
IF = 10.162 (2016)

浦野 健辰巳 香澄、関根 浄治:新規モノクローナル抗体、及びそのタグ抗体としての利用、特許第5928734号 (P5928734)
権利者国立大学法人島根大学
登録日平成28年5月13日
出願番号 特願2013-504734、出願日平成24年3月13日

2015
Yoshida H, Park S-Y, Oda T, Akiyoshi T, Sato M, Shirouzu M, Tsuda K, Kuwasako K, Unzai S, Yutaka Muto Y, Urano T and Obayashi E: Novel 3' splice-site recognition by the two zinc fingers in the U2AF small subunit
Gene Dev 29: 1649-1660, 2015 doi: 10.1101/gad.267104.115
IF = 10.042 【Times Cited: 16】

Sekine J, Nakatani E, Ohira K, Hideshima K, Kanno T, Kagimura T and Urano T: Nucleus accumbens-associated protein 1 Expression Has Potential as a Marker for Distinguishing Oral Epithelial Dysplasia and Squamous Cell Carcinoma
PLOS ONE 10(7): e0131752, 2015. doi: 10.1371/journal.pone.0131752
IF = 3.057 【Times Cited: 2】

Verrier L, Taglini F, Barrales RR, Webb S, Urano T, Braun S and Bayne EH: Global regulation of heterochromatin spreading by Leo1.
Open Biol 5: 150045, 2015 doi: 10.1098/rsob.150045
IF = 4.822 【Times Cited: 10】

Miyake T, Honma Y, Urano T, Kato N and Suzumiya J.: Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells.
Int J Oncol 47: 315-324, 2015 doi: 10.3892/ijo.2015.2979.
IF = 3.018 【Times Cited: 8】

Ohira K, Hideshima K, Urano T and Sekine J.: Is Nucleus Accumbens-Associated Protein 1 a feasible marker for distinguishing oral malignancies form non-malignancies? First investigation of Nucleus Accumbens-Associated Protein 1 expression in oral lesions.
Shimane J Med Sci
31: 29-41, 2015

Makino R, Obayashi E, Hori H, Iizuka T, Mashima K, Shiro Y, and Ishimura Y.: Initial O-2 Insertion Step of the Tryptophan Dioxygenase Reaction Proposed by a Heme-Modification Study
Biochemistry 54: 3604-3616, 2015 doi: 10.1021/acs.biochem.5b00048
IF = 2.8761 【Times Cited: 3】

尾林 栄治浦野 健: RNAスプライシングの構造生物学的研究
島根医学 35:1-7, 2015

岡崎宏亮成相裕子加藤太陽浦野健:物質相互作用をリアルタイムに可視化する技術、特許第5831867号 ( P5831867)
権利者:国立大学法人島根大学
登録日:平成27年11月6日
出願番号:特願2011-076772
出願日:平成23年3月30日


2014
Kato T, Enomoto A, Watanabe T, Haga H, Ishida S, Kondo Y, Furukawa K, Urano T, Mii S, Weng L, Ishida-Takagishi M, Asai M, Asai N, Kaibuchi K, Murakumo Y and Takahashi M: TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives.
Cell Rep 7: 1156-1167, 2014 【Times Cited: 17】
IF = 7.870
doi:10.1016/j.celrep.2014.03.068

Moriyama T, Fujimitsu Y, Yoshikai Y, Sasano T, Yamada K, Murakami M, Urano T, Sugasawa K and Saitoh H: SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells.
Biochem Biophys Res Commun 447: 419-424, 2014 【Times Cited: 7】
IF = 2.371
doi:10.1016/j.bbrc.2014.04.004

Saito M, Fujimitsu Y, Sasano T, Yoshikai Y, Ban-Ishihara R, Nariai Y, Urano T and Saitoh H: The SUMO-targeted ubiquitin ligase RNF4 localizes to etoposide-exposed mitotic chromosomes: Implication for a novel DNA damage response during mitosis.
Biochem Biophys Res Commun 447: 83-88, 2014 【Times Cited: 5】
IF = 2.371
doi:10.1016/j.bbrc.2014.03.106

Kamata K, Goswami G, Kashio S, Urano T, Nakagawa R, Uchida H and Oki M.: The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function.
J Biochem 155: 159-171, 2014 doi: 10.1093/jb/mvt108
IF = 2.397 【Times Cited: 6】

【特許出願】朴 三用、浦野 健成相 裕子、杉山 佳奈子. 「インフルエンザウイルスのRNA依存性RNAポリメラーゼのPB2サブユニットに対するモノクローナル抗体」特願2014-68824、平成26年3月28日出願



200回以上citationされた論文 (ISI 060718調べ)年代順
Kondo Y, Shen L, Cheng A, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang T H-U and Issa J-P J.: Gene silencing in cancer by histone H3 lysine 27 tri-methylation independent of promoter DNA methylation.
Nature Genet. 40: 741-750, 2008 【Times Cited: 409】

Urano T, Emkey R and Feig LA.: Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
EMBO J 15: 810-816, 1996 【Times Cited: 289】

Jiang H, Luo JQ, Urano T, Frankel P, Lu Z, Foster DA and Feig LA.: Involvement of Ral GTPase in v-Src-induced phospholipase D activation.
Nature 378: 409-412, 1995 【Times Cited: 242】

Cantor SB*, Urano T* and Feig LA. (*These two authors contributed equally): Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases.
Mol Cell Biol 15: 4578-4584, 1995 【Times Cited: 236】


100回以上citationされた論文 (ISI 060718調べ)年代順
Folco HD, Pidoux AL, Urano T and Allshire RC.: Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres.
Science 319: 94-97, 2008 【Times Cited: 114】

Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, Tame JRH and Park SY.: The structural basis for an essential subunit interaction in influenza virus RNA polymerase.
Nature 454: 1127-1131, 2008 【Times Cited: 121】

Goto H, Kiyono T, Tomono Y, Kawajiri A, Urano T, Furukawa K, Nigg EA and Inagaki M.: Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.
Nature Cell Biol 8: 180-187, 2006 【Times Cited: 114】

Kato H, Goto DB, Martienssen RA, Urano T, Furukawa K and Murakami Y.: RNA polymerase II is required for RNAi-dependent heterochromatin assembly.
Science 309: 467-469, 2005 【Times Cited: 198】

Sadaie M, Iida T, Urano T and Nakayama JI. : A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.
EMBO J 23:3825-3835, 2004 【Times Cited: 128】

Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K and Urano T.: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
J Biol Chem 279: 47201-47211, 2004 【Times Cited: 118】

Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I and Inagaki M.: Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.
J Biol Chem 279: 12997-13003, 2004 【Times Cited: 133】


Nakagawachi T, Soejima H, Urano, T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M and Mukai T.: Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
Oncogene 22: 8835-8844, 2003 【Times Cited: 113】

Sugiyama K, Sugiura K, Hara T, Sugimoto K, Shima H, Honda K, Furukawa K, Yamashita S and Urano T.: Aurora-B associated protein phosphatases as negative regulators of kinase activation.
Oncogene
21: 3103-3111, 2002 【Times Cited: 113】

Honda K, Mihara H, Kato Y, Yamaguchi A, Tanaka H, Yasuda H, Furukawa K and Urano T.: Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway.
Oncogene 19: 2812-2819, 2000 【Times Cited: 114】

Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T and Furukawa K.: Molecular cloning of a novel a2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.
J Biol Chem 274: 11479-11486, 1999 【Times Cited: 104】

Tanaka K, Nishide J, Okazaki K, Kato H, Niwa O, Nakagawa T, Matsuda H, Kawamukai M and Murakami Y.: Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation.
Mol Cell Biol 19: 8660-8672, 1999 【Times Cited: 144】

Okajima T, Fukumoto S, Furukawa K, Urano T and Furukawa K.: Molecular basis for the progeroid variant of Ehlers-Danlos syndrome.: Identification and characterization of two mutations in galactosyltransferase I gene.
J Biol Chem 274: 28841-28844, 1999 【Times Cited: 103】

Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, Hirai H and Morimoto C.: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
J Biol Chem 272: 29083-29090, 1997 【Times Cited: 130】

Park SY, Shimizu H, Adachi S, Nakagawa A, Tanaka I, Nakahara K, Shoun H, Obayashi E, Nakamura H, Iizuka T and Shiro Y.: Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum
Nature Struct Biol 4: 827-832, 1997 【Times Cited: 156】

Feig LA, Urano T and Cantor SB.: Evidence for a Ras/Ral signaling cascade.
Trends Biochem Sci 21: 438-441, 1996 (Review) 【Times Cited: 178】

Tokunaga Y, Urano T, Furukawa K, Kondo H, Kanematsu T and Shiku H.: Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer.
Int J Cancer 55: 66-71, 1993 【Times Cited: 149】


50回以上citationされた論文 (ISI 060718調べ)年代順
Sugiyama K, Obayashi E, Kawaguchi A, Suzuki Y, Tame JRH, Nagata K and Park SY.: Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase.
EMBO J 28: 1803-1811, 2009 【Times Cited: 89】

Kagansky A, Folco HD, Almeida R, Pidoux AL, Boukaba A, Simmer F, Urano T, Hamilton GL and Allshire RC.: Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres.
Science 324:1716-1719, 2009 【Times Cited: 85】

Bayne EH, Portoso M, Kagansky A, Alves F, Urano T, Ekwall K, Rappsilber J and Allshire RC.: Splicing factors facilitate RNAi-directed silencing in fission yeast
Science 322: 602-606, 2008 【Times Cited: 80】

Nishikawa N1, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, and Tokino T.: Gene amplification and overexpression of PRDM14 in breast cancers.
Cancer Res 67: 9649-9657, 2007 【Times Cited: 66】

Ohashi S, Sakashita G, Ban R, Nagasawa M, Matsuzaki H, Murata Y, Taniguchi H, Shima H, Furukawa K and Urano T.: Phospho-regulation of human Protein Kinase Aurora-A: Analysis using anti-phospho-Thr288 monoclonal antibodies.
Oncogene 25: 7691-7702, 2006 【Times Cited: 65】

Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, Wiels J, Urano T, Tajima O, Furukawa K and Furukawa K.: Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins.
J Biol Chem 281: 10230-10235, 2006 【Times Cited: 104】

Kanoh J, Sadaie M, Urano T and Ishikawa F.: Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres.
Curr Biol 15:1808-1819, 2005 【Times Cited: 88】

Yamasaki Y, Kayashima T, Soejima H, Kinoshita A, Yoshiura K, Matsumoto N, Ohta T, Urano T, Masuzaki H, Ishimaru T, Mukai T, Niikawa N and Kishino T.: Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air.
Hum Mol Genet 14: 2511-2520, 2005 【Times Cited: 55】

Nguyen HG, Chinnappan D, Urano T and Ravid K.: Mechanism of aurora-B degradation and its dependency on intact KEN and A-boxes: Identification of an aneuploidy-promoting property
Mol Cell Biol 25: 4977-4992, 2005 【Times Cited: 95】

Hamamura K, Furukawa K, Hayashi T, Hattori T, Nakano J, Nakashima H, Okuda T, Mizutani H, Hattori H, Ueda M, Urano T, Lloyd KO and Furukawa K.: Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.
Proc Natl Acad Sci USA 102: 11041-11046, 2005 【Times Cited: 76】

Nishio M, Fukumoto S, Furukawa K, Ichimura A, Miyazaki H, Kusunoki S, Urano T and Furukawa K.: Overexpressed GM1 suppresses NGF signals by modulating the intra-cellular localization of NGF receptors and membrane fluidity in PC12 cells.
J Biol Chem 279: 33368-33378, 2004 【Times Cited: 75】

Mitsuhashi S, Shima H, Tanuma N, Matsuura N, Takehawa M, Urano T, Kataoka T, Ubukata M and Kikuchi K.: Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo
J Biol Chem 278: 82-88, 2004 【Times Cited: 63】

Satoh A, Toyota M, Ikeda H, Morimoto Y, Akino K, Mita H, Suzuki H, Sasaki Y, Kanaseki T, Takamura Y, Soejima H, Urano T, Yanagihara K, Endo T, Hinoda Y, Fujita M, Hosokawa M, Sato N, Tokino T, and Imai K.: Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.
Oncogene 23: 8876-8886, 2004 【Times Cited: 55】

Taguchi S, Honda K, Sugiura K, Yamaguchi A, Furukawa K and Urano T.: Degradation of human Aurora-A protein kinase is mediated by hCdh1
FEBS Lett 519: 59-65, 2002 【Times Cited: 76】

Mitsuda T, Furukawa K, Fukumoto S, Miyazaki H, Urano T and Furukawa K.: Over-expression of ganglioside GM1 results in the dispersion of platelet derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals.
J Biol Chem 277: 11239-11246, 2002 【Times Cited: 77】

Fukumoto S, Mutoh T, Hasegawa T, Miyazaki H, Okada M, Goto G, Furukawa K, Urano T and Furukawa K.: GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation.
J Biol Chem 275: 5832-5838, 2000 【Times Cited: 82】

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M and Furukawa K.: Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids
J Biol Chem 275: 15152-15156, 2000 【Times Cited: 82】

Shimizu H, Obayashi E, Gomi Y, Arakawa H, Park SY, Nakamura H, Adachi S, Shoun H and Shiro Y.: Proton delivery in NO reduction by fungal nitric-oxide reductase - Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.
J Biol Chem 275: 4816-4826, 2000 【Times Cited: 79】

Goi T, Rusanescu G, Urano T and Feig LA.: Ral-specific guanine nucleotide exchange factor activity opposes other ras effectors in PC12 cells by inhibiting neurite outgrowth.
Mol Cell Biol 19: 1731-1741, 1999 【Times Cited: 77】

Sterpetti P, Hack AA, Bashar MP, Park B, Cheng SD, Knoll JH, Urano T, Feig LA and Toksoz D.: Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting.
Mol Cell Biol 19:1334-1345, 1999 【Times Cited: 58】

Makino R, Matsuda H, Obayashi E, Shiro Y, Iizuka T and Hori H.: EPR characterization of axial bond in metal center of native and cobalt-substituted guanylate cyclase.
J Biol Chem 274:7 714-7723, 1999 【Times Cited: 60】

Expression of DCC protein in colorectal tumors and its relationship to tumor progression and metastasis.
Saito M, Yamaguchi A, Goi T, Tsuchiyama T, Nakagawara G, Urano T, Shiku H, Furukawa K.
Oncology 56: 134-141, 1999 【Times Cited: 51】

Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats.
Okajima T1, Fukumoto S, Ito H, Kiso M, Hirabayashi Y, Urano T, Furukawa K.
J Biol Chem, 274: 30557-30562, 1999 【Times Cited: 51】

Yamaguchi A*, Urano T*, Goi T and Feig LA. (*These two authors contributed equally): An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.
J Biol Chem 272: 31230-31234, 1997 【Times Cited: 93】

Obayashi E, Tsukamoto K, Adachi S, Takahashi S, Nomura M, Iizuka T, Shoun H and Shiro Y.: Unique binding of nitric oxide to ferric nitric oxide reductase from Fusarium oxysporum elucidated with infrared, resonance Raman, and X-ray absorption spectroscopies.
J Am Chem Soc 119: 7807-7816, 1997 【Times Cited: 77】

Yamaguchi A, Urano T, Goi T, Saito M, Takeuchi K, Hirose K, Nakagawara G, Shiku H and Furukawa K.: Expression of a CD44 variant containing exons 8-10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients.
J Clin Oncol 14: 1122-1127, 1996 【Times Cited: 83】

OkabeKado J, Kasukabe T, Hozumi M, Honma Y, Kimura N, Baba H, Urano T and Shiku H.: A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it’s kinase activity.
FEBS Lett 363: 311-315, 1995 【Times Cited: 68】

Baba H, Urano T, Okada K, Furukawa K, Nakayama E, Tanaka H, Iwasaki K and Shiku H.: Two isotypes of murine nm23/nucleoside diphosphate kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line.
Cancer Res 55: 1977-1981, 1995 【Times Cited: 84】

Shiro Y, Fujii M, Isogai Y, Adachi S, Iizuka T, Obayashi E, Makino R, Nakahara K and Shoun H.: Iron-ligand structure and iron redox property of nitric oxide reductase cytochrome P450nor from Fusarium oxysporum: relevance to its NO reduction activity.
Biochemistry 34: 9052-9058, 1995 【Times Cited: 52】

Yamaguchi A, Urano T, Goi T, Takeuchi K, Niimoto S, Nakagawara G, Furukawa K and Shiku H.: Expression of human nm23-H1 and nm23-H2 proteins in hepatocellular carcinoma.
Cancer 73: 2280-2284, 1994 【Times Cited: 89】

Yamaguchi A, Urano T, Fushida S, Furukawa K, Nishimura G, Yonemura Y, Miyazaki I, Nakagawara G and Shiku H.: Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis.
Br J Cancer 68: 1020-1024, 1993 【Times Cited: 74】

Konishi N, Nakaoka S, Tsuzuki T, Matsumoto K, Kitahori Y, Hiasa Y, Urano T and Shiku H.: Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma.
Jpn J Cancer Res 84: 1050-1054, 1993 【Times Cited: 73】

Motojima K, Urano T, Nagata Y, Shiku H, Tsurifune T and Kanematsu T.: Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma.
Ann Surg 217: 138-143, 1993 【Times Cited: 94】

Urano T, Furukawa K and Shiku H.: Expression of nm23/NDP kinase proteins on the cell surface.
Oncogene 8: 1371-1376, 1993 【Times Cited: 73】

Urano T, Takamiya K, Furukawa K and Shiku H.: Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2.
FEBS Lett 309: 358-362, 1992 【Times Cited: 83】

Motojima K, Urano T, Nagata Y, Shiku H, Tsunoda T and Kanematsu T.: Mutations in the kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma.
Am J Gastroenterol 86: 1784-1788, 1991 【Times Cited: 68】

Motojima K, Tsunoda T, Kanematsu T, Nagata Y, Urano T and Shiku H.: Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene.
Ann Surg 214: 657-662, 1991 【Times Cited: 95】

 








 
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