Arterial stiffness increases with normal aging, metabolic syndrome, and diabetes. Arterial stiffness is also a cholesterol-independent risk factor for a cardiovascular event. Recently the ability of biomechanical properties has been increasingly known. The stiffness of tissue and microenvironment provide the responsible for controlling cellular behavior and differentiation. In order to better understand the vascular mechanobiology, we are trying to elucidate how the vascular stiffness promotes the endothelial cellular dysfunction in the context of cardiovascular diseases.
