Research Themes

1. Molecular carcinogenesis of gynecological tumors
   Our research targets genomics, epigenomics, and proteomics in the development of gynecological malignancies, focusing on the multistep carcinogenesis and tumor microenvironments, especially with in vitro/vivo carcinogenesis models and spheroid/organoid models. The ultimate aims of our research are the establishment of molecular-targeted therapies for personalized medicine, with clinical samples including cancer stem fractions, next-generation sequencing, and RNA editing.
2. Mechanisms of regulation of hypothalamic-pituitary-gonadal axis
   The endocrine and infertility group focuses on the regulation of the hypothalamic-pituitary-gonadal axis, which governs the estrogen synthesis, ovulation, and maintains menstrual cycles in reproductive women, investigating the mechanisms of how hypothalamic kisspeptin neurons are regulated by various neuroendocrine peptides. Especially, the following points are rigorously analyzed.

• Cellular mechanisms of GnRH synthesis and release by kisspeptin neurons
• Differential regulation of pituitary gonadotropin subunits by different frequencies of GnRH pulse
• Examining of the local roles of hypothalamic neuropeptides in peripheral tissues