Metabolic Biochemistry

Research Themes

The regulation of bone marrow homeostasis by chromatin modifiers and its dysregulation in hematological malignancies.

Details

We have been engaging in basic hematopoietic stem cell (HSC) research. Our research aims to develop new therapeutic strategies to prevent and cure hematological malignancies. Our current research focuses on genes that encode chromatin modifiers and their somatic mutations to elucidate the mechanisms underlying the regulation of HSC and the onset of hematological malignancies. 

For further reading
1. Miyagi et al., Blood, 2019
2. Miyagi & Iwama, Curr Opin Hematol., 2020
3. Kato et al., Exp Hematol., 2019 
4. Miyagi et al., Inflamm. Regen., 2022