Research Themes

We focus on dendritic cells, macrophages, and mesenchymal cells to develop novel cancer immunotherapies and human immunological disease models.

1. Elucidation and application of the self-recognition mechanism in dendritic cells
2. Development of human immunological disease models using humanized mice
3. Development of novel cancer immunotherapies targeting macrophages
4. Development of innovative cancer therapies using mesenchymal stem cells

Details

1. Investigation of the CD47 recognition mechanism in dendritic cells and its application to autoimmunity and cancer immunity
2. Development of human cancer immunotherapy and human infection models using mice with a human immune system
3. Development of cancer immunotherapies targeting SIRPα, a checkpoint molecule expressed on macrophages
4. Establishment of novel cancer therapies using chemokine-producing mesenchymal stem cells