Internal Medicine I
Research Themes
In the Department of Internal Medicine 1, we are focusing on the following four major research topics
- Diabetic complication research primarily focusing on kidney complications.
- Disruption of bone metabolism in the systemic endocrine/metabolic diseases.
- The biology of Cancer in Diabetes.
- Exploration of the pathogenesis and novel therapeutic strategy in Preeclampsia.
Details
- Regarding the research focusing on kidney complications surrounding Diabetes, we have set out to investigate into the molecule responsible for systemic organ damage including that concerning the cardio-renal connection.
- For the osteometabolic and endocrine/ metabolic disorders, we have initiated basic research on not only the correlation with clinical biomarkers, but also are conducting analyses on molecular mechanisms of local and systemic hormone regulation.
- For the relationship between Diabetes and Cancer, we are conducting analyses paying particular attention to the connection between the complex regulatory network and metabolic dysfunction in the Cancer microenvironment.
- Preeclampsia is a devastating complication of pregnancy. We have reported the role of catechol metabolism defects and a potential deficiency in the placental renin-regulated transcription factor in the pathogenesis of Preeclampsia. Our goal is to target these pathogenic mechanisms and explore novel therapeutic strategies to combat Preeclampsia.