Our Publications

2024 2023 2022 2021 2020 2019 2018 2017 2016 ~2015

2025

• [Review]
  Watanabe S, Yamanaka K: Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases. Bioessays 4: e70016, 2025.

2024

• Horiuchi M, Watanabe S, Komine O, Takahashi E, Kaneko K, Itohara S, Shimada M, Ogi T, Yamanaka K: ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice. Acta Neuropathologica Communications 12: 184, 2024.
  Press release from Nagoya Univ
• Sobue A, Komine O, Endo F, Kakimi C, Miyoshi Y, Kawade N, Watanabe S, Saito Y, Murayama S, Saido SC, Saito T, Yamanaka K: Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation. Cell Death & Diseaae 15: 858, 2024.
• Watanabe S, Amporndanai K, Awais R, Latham C, Awais M, O'Neill PM, Yamanaka K, Hasnain S: Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Scientific Reports 14, 12118, 2024.
• Wang T, Sobue A, Watanabe S, Komine O, Saido TC, Saito T, Yamanaka K: Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease. Journal of Neuroinflammation 21(1), 55, 2024.
• Komine O, Ohnuma S, Hinohara K, Hara Y, Shimada M, Akashi T, Watanabe S, Sobue A, Kawade N, Ogi T, Yamanaka K: Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. iScience 27(2), 108872, 2024.
  Press release from Nagoya Univ

2023

• Watanabe S, Murata Y, Oka Y, Oiwa K, Horiuchi M, Iguchi Y, Komine O, Sobue A, Katsuno M, Ogi T, Yamanaka K: Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. Proceedings of the National Academy of Sciences of the United States of America 120(47): e2315347120, 2023.
  Press release from Nagoya Univ
• Oiwa K, Watanabe S, Onodera K, Iguchi Y, Kinoshita Y, KOmine O, Sobue A, Okada Y, Katsuno M, Yamanaka K: Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis. Science Advances 9(31): eadf6895, 2023.
  Press release from Nagoya Univ
• Hashimoto K, Watanabe S, Akutu M, Mukai N, Kamishina H, Furukawa Y, Yamanaka K: Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy–linked E40K mutation. Journal of Biological Chemistry 299(6): 104798, 2023.
  Press release from Nagoya Univ
• Watanabe S, Horiuchi M, Murata Y, Komine O, Kawade N, Sobue A, Yamanaka K: Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis. Neurobiology of Disease 2: 179 106031, 2023.
  Press release from Nagoya Univ

2021

• Sakai S, Watanabe S, Komine O, Sobue A, and Yamanaka K: Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis. FASEB Journal e21688, 2021.
  
• Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T, Sahara N, Higuchi M, Ogi T and Yamanaka K: Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease. Acta Neuropathologica Communications 9: 1, 2021.
  Press release from Nagoya Univ

2020

• Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K: Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Cell Death & Disease 11: 909, 2020.
  Press release from Nagoya Univ
• Amporndanai K, Rogers M, Watanabe S, Yamanaka K, O’Neill P. M., Hasnain S. S.: Novel Selenium-based compounds with therapeutic potential for SOD1-linked Amyotrophic Lateral Sclerosis. EBioMedicine 59: 102980, 2020.
  Press release from Nagoya Univ
• Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K: ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration. Molecular Brain 13: 8, 2020.

2019

• Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K: Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Acta Neuropathologica Communications 7(1): 118, 2019.

2018

• Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K: Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death & Differentiation 25: 2130-2146, 2018.
  Press release from Nagoya Univ
• Tokuda E, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y: A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis. Biochimica et Biophysica Acta 1864(6): 2119-2130, 2018.

2017

• Watanabe S, Komine O, Fumito E, Wakasugi K, Yamanaka K: Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice. Journal of Neurochemistry 145(1): 80-89, 2017.
• Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K: TDP-43 accelerates age-dependent degeneration of interneurons. Scientific Reports 7: 14972, 2017.
  
• Takahashi N, Onozuka W, Watanabe S, Wakasugi K: Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. FEBS Open Bio 7: 1338-1349, 2017.
• Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y: Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. Molecular Neurodegeneration 12: 2, 2017.

2016

• Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K: Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. EMBO Molecular Medicine 8(12): 1421-1437, 2016.
  
• Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K: Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta Neuropathologica Communications 4: 15, 2016
  

~2015

• Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, *Yamanaka K, Mishra A: Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. Neurobiology of Disease 86: 16, 2015.
  
• Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, *Yamanaka K: Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells. Cell Reports 11: 592, 2015.
  
• Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K: Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. Cell Death & Disease, 5: e1497, 2014.
• Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, *Yamanaka K: SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Molecular Brain 7: 62, 2014.
  
• Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS: Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the Natural Academy of Sciences, USA 111: 4309-4314, 2014.
• Takahashi N, Watanabe S, Wakasugi K: Crucial Roles of Glu60 in Human Neuroglobin as a Guanine Nucleotide Dissociation Inhibitor and Neuroprotective Agent. PLOS ONE 8: e83698, 2013.
• Kamioka Y, Fujikawa C, Ogai K, Sugitani K, Watanabe S, Kato S, Wakasugi K: Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells. Biochimica et Biophysica Acta 1834: 1779-1788, 2013.
• Watanabe S, Takahashi N, Uchida H, Wakasugi K: Human Neuroglobin Functions as an Oxidative Stress-responsive Sensor for Neuroprotection. Journal of Biological Chemistry 287: 30128-30138, 2012.
• [Review]
  Wakasugi K, Watanabe S: Species-specific functional evolution of neuroglobin. Marine Genomics 4: 137-142, 2011.
• Wakasugi K, Takahasi N, Watanabe S: Chimeric ZHHH neuroglobin is a novel cell-membrane-penetrating, neuroprotective agent. Amerincan Journal of Neuroprotection and Neurodegeneration 3: 42-47, 2011.
• Watanabe S, Wakasugi K: Module M1 of Zebrafish Neuroglobin Acts as a Structural and Functional Protein Building Block for a Cell-Membrane-Penetrating Activity. PLOS ONE 6: e16808, 2011.
• Watanabe S, Wakasugi K: Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin. FEBS Letters 584: 2467-2472, 2010.
• Watanabe S, Wakasugi K: Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity. Biochimical and Biophysical Reseach Communications 369: 695-700, 2008.
• Watanabe S, Wakasugi K: Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry 47: 5266-5270, 2008.