PUBLICATIONS

2025

2024

  1. Iida Y, Harada M.
    Local cell therapy using CCL19-expressing allogeneic mesenchymal stem cells exerts robust antitumor effects by accumulating CD103+ IL-12-producing dendritic cells and priming CD8+ T cells without involving draining lymph nodes.
    J Immunother Cancer. 2024 Dec 10;12(12):e009683. doi: 10.1136/jitc-2024-009683.
    Topics(JP)(Shimane University).
  2. Martins TA, Kaymak D, Tatari N, Gerster F, Hogan S, Ritz MF, Sabatino V, Wieboldt R, Bartoszek EM, McDaid M, Gerber A, Buck A, Beshirova A, Heider A, Shekarian T, Mohamed H, Etter MM, Schmassmann P, Abel I, Boulay JL, Saito Y, Mariani L, Guzman R, Snijder B, Weiss T, Läubli H, Hutter G.
    Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker.
    Nat Commun. 2024 Nov 9;15(1):9718. doi: 10.1038/s41467-024-54129-w.
  3. Kotani H, Han W, Iida Y, Tanino R, Katakawa K, Okimoto T, Tsubata Y, Isobe T, Harada M.
    Therapeutic Senolysis of Axitinib-Induced Senescent Human Lung Cancer Cells.
    Cancers (Basel). 2024 Aug 7;16(16):2782. doi: 10.3390/cancers16162782.
  4. Harada M, Kotani H, Iida Y, Tanino R, Minami T, Komohara Y, Yoshikawa K, Uemura H.
    Hypoxia-related carbonic anhydrase 9 induces serpinB9 expression in cancer cells and apoptosis in T cells via acidosis.
    Cancer Sci. 2024 May;115(5):1405-1416. doi: 10.1111/cas.16133.
  5. Theocharides APA, Hutter G, Saito Y.
    Editorial: The therapeutic inhibition of macrophage checkpoints.
    Front Immunol. 2024 Apr 26:15:1418281. doi:10.3389/fimmu.2024.1418281.

2023

  1. Saito Y*, Iida-Norita R, Afroj T, Refaat A, Hazama D, Komori S, Ohata S, Takai T, Oduori OS, Kotani T, Funakoshi Y, Koma YI, Murata Y, Yakushijin K, Matsuoka H, Minami H, Yokozaki H, Manz MG, Matozaki T.
    Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models.
    Front Immunol. 2023 Dec 14:14:1294814. doi: 10.3389/fimmu.2023.1294814.
    Kobe University News (EN).
  2. Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordoñez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H.
    THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
    Nat Commun. 2023 Sep 25;14(1):5534. doi:10.1038/s41467-023-41095-y.
  3. Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T.
    Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
    J Exp Med. 2023 Nov 6;220(11):e20220681. doi: 10.1084/jem.20220681.
  4. Komori S, Saito Y*, Nishimura T, Respatika D, Endoh H, Yoshida H, Sugihara R, Iida-Norita R, Afroj T, Takai T, Oduori OS, Nitta E, Kotani T, Murata Y, Kaneko Y, Nitta R, Ohnishi H, Matozaki T.
    CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis.
    Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2304943120. doi: 10.1073/pnas.2304943120.
    Kobe University News (EN).
  5. Okamoto T, Murata Y, Hasegawa D, Yoshida M, Tanaka D, Ueda T, Hazama D, Oduori OS, Komori S, Takai T, Saito Y, Kotani T, Kosaka Y, Maniwa Y, Matozaki T.
    Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.
    Cancer Sci. 2023 May;114(5):1871-1881. doi: 10.1111/cas.15758.

2022

  1. Saito Y*, Komori S, Kotani T, Murata Y, Matozaki T.
    The role of type-2 conventional dendritic cells in the regulation of tumor immunity (Review).
    Cancers (Basel). 2022 Apr 13;14(8):1976. doi: 10.3390/cancers14081976.
  2. Harada M, Iida Y, Kotani H, Minami T, Komohara Y, Eto M, Yoshikawa K, Uemura H.
    T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.
    Cancer Immunol Immunother. 2022 Feb;71(2):339-352. doi: 10.1007/s00262-021-02992-7.
  3. Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A, Fukada SI.
    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
    Cell Stem Cell. 2022 Feb 3;29(2):265-280.e6. doi: 10.1016/j.stem.2021.11.003.

2021

  1. Saito Y, Willinger T, Theocharides APA.
    Editorial: Advances in Human Immune System Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy.
    Front Immunol. 2021 Dec 23:12:829644. doi: 10.3389/fimmu.2021.829644.
  2. Sakamoto M, Murata Y, Tanaka D, Kakuchi Y, Okamoto T, Hazama D, Saito Y, Kotani T, Ohnishi H, Miyasaka M, Fujisawa M, Matozaki T.
    Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages.
    Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2109923118. doi: 10.1073/pnas.2109923118.
  3. Matozaki T, Kotani T, Murata Y, Saito Y.
    Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis.
    Cancer Sci. 2021 Jan;112(1):16-21. doi: 10.1111/cas.14702.

2020

  1. Franke K, Pillai SY, Hoogenboezem M, Gijbels MJJ, Matlung HL, Geissler J, Olsman H, Pottgens C, van Gorp PJ, Ozsvar-Kozma M, Saito Y, Matozaki T, Kuijpers TW, Hendriks RW, Kraal G, Binder CJ, de Winther MPJ, van den Berg TK.
    SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production.
    Front Immunol. 2020 Oct 9:11:570963. doi: 10.3389/fimmu.2020.570963.
  2. Rafiei A, Wilk CM, Helbling PM, Myburgh R, Saito Y, Haralambieva E, Soldini D, Chakraborty R, Merad M, Allen CE, Nombela-Arrieta C, Manz MG.BRAFV 600E or mutant MAP2K1 human CD34+ cells establish Langerhans cell-like histiocytosis in immune-deficient mice.
    Blood Adv. 2020 Oct 13;4(19):4912-4917. doi: 10.1182/bloodadvances.2020001926.
  3. Hazama D, Yin Y, Murata Y, Matsuda M, Okamoto T, Tanaka D, Terasaka N, Zhao J, Sakamoto M, Kakuchi Y, Saito Y, Kotani T, Nishimura Y, Nakagawa A, Suga H, Matozaki T.
    Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy.
    Cell Chem Biol. 2020 Sep 17;27(9):1181-1191.e7. doi: 10.1016/j.chembiol.2020.06.008.
  4. Nishimura T, Saito Y*, Washio K, Komori S, Respatika D, Kotani T, Murata Y, Ohnishi H, Mizobuchi S, Matozaki T.
    SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis.
    Eur J Immunol. 2020 Oct;50(10):1560-1570. doi: 10.1002/eji.201948410.
  5. Taniura T, Iida Y, Kotani H, Ishitobi K, Tajima Y, Harada M.
    Immunogenic chemotherapy in two mouse colon cancer models.
    Cancer Sci. 2020 Oct;111(10):3527-3539. doi: 10.1111/cas.14624.
  6. Iida Y, Yoshikawa R, Murata A, Kotani H, Kazuki Y, Oshimura M, Matsuzaki Y, Harada M.
    Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells.
    J Immunother Cancer. 2020 Jul;8(2):e000582. doi: 10.1136/jitc-2020-000582.
  7. Satoh Y, Kotani H, Iida Y, Taniura T, Notsu Y, Harada M.
    Supplementation of l-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy.
    Cancer Sci. 2020 Jul;111(7):2248-2258. doi: 10.1111/cas.14490.
  8. Okimoto T, Kotani H, Iida Y, Koyanagi A, Tanino R, Tsubata Y, Isobe T, Harada M.
    Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells.
    Cancer Sci. 2020 Jun;111(6):1910-1920. doi: 10.1111/cas.14401.
  9. Wang B, Saito Y, Nishimura M, Ren Z, Tjan LH, Refaat A, Iida-Norita R, Tsukamoto R, Komatsu M, Itoh T, Matozaki T, Mori Y.
    An Animal Model That Mimics Human Herpesvirus 6B Pathogenesis.
    J Virol . 2020 Feb 28;94(6):e01851-19. doi: 10.1128/JVI.01851-19.
     HHV-6 Foundation HP